The music video for the song takes place on an commercial airliner, parodying the movie Airplane!, and by extension, the films Airport 1975 and its sequel Airport '77. Two airline mechanics (played by Jack Black and Kyle Gass from Tenacious D) smuggle and hide their narcotic known as "World Domination brand 'Erotic' Sleeping Powder" in the coffee-maker. This ends up incapacitating everyone who drinks the coffee. The video for the song was directed by Jesse Peretz.
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References Airport '77