On the topic of History's Greatest Invention Since 1950, the six items up for consideration between Craig and the panelists - inventor entrepreneur Lori Greiner, actor comedian Kate Flannery and singer Trace Adkins - are: the Internet; the microwave oven; the personal computer; Viagra; Velcro; and the jet airliner. Before the discussion, Craig explains why the list has been narrowed to since 1950, and that all on the list have on the most part improved society. Beyond looking at the merits of each, the panelists discuss what may be their criteria, such as taking points off if the invention was the result of a mistake, if it was come upon by accident, or if it has had some unintended negative consequences on the world. Some positive criteria may be the scope of how the invention has affected the world, and the measure of how it has improved life. They also mention inventions that did not make the list but perhaps should have.