A disillusioned ER doctor finds his existence transformed when he intervenes in a drive-by shooting, saving a young boy's life and killing one of his attackers. When he learns the boy is still marked for death, he finds himself compelled to save him.
When Antoine disappears from his bed at the Surgical Center, John must find him quickly or face the consequences of losing a gang leader's son. Gretchen tries to convince a combative patient, Hillary, to lie about her medical condition in order to keep John clear of Bridget's suspicions.
John visits Antoine's father, the leader of the VCC gang, in prison, and tries to disentangle himself from his responsibilities with Antoine. Meanwhile, things get out of control when Gretchen confronts Hillary's abusive boyfriend at his home.
Gretchen makes expensive arrangements to hide Antoine in order to prevent Bridget from learning that John illegally transferred him to the surgical center. That means John needs to ask the gang for money, however.
When the victims of a gang shootout spill into the ER, John must navigate rival gang members and the police while trying to halt the escalating violence. Meanwhile, Gretchen tends to the young woman who sparked the recent bloodshed.